Tag: drugs

Combating Chemoresistance by Targeting DNA Repair

Combating Chemoresistance: Blocking DNA Repair to Fight Cancer

Combating Chemoresistance by Targeting DNA Repair
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In 2012, the most recent year for which the information is available, there were 8.2 million cancer-related deaths worldwide. Chemotherapy is a common treatment resort, but it’s by no means a magic bullet, and this is often due to chemoresistance. This latest Chemunicate graphic, made on behalf of Thomas Fleming at the University of Oxford, looks at how understanding this process can help chemists develop new drugs to tackle the problem. 

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Finding More Stable Drugs Using Full Interaction Maps

Finding More Stable Forms of Drugs Using Full Interaction Maps

Finding More Stable Drugs Using Full Interaction Maps
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When pharmaceutical companies manufacture a drug, finding the drug’s most stable form is important. Not only do drugs become less effective as they degrade, limiting their useful shelf life, but if a more stable version of a drug is discovered after it has reached the market, products may end up being withdrawn, costing money. As a result, chemists are developing methods to evaluate drug stability, and using a “Full Interaction Maps” tool is one such computational method.

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