Medicinal Chemistry

Understanding the Drug Discovery Process

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Drug testing was in the news on Friday – though this time it wasn’t the usual sports doping headlines, but instead news of the clinical trial of a drug gone tragically wrong in France. Of the 90 people given the drug in a phase 1 clinical trial, one has been left with permanent brain damage, and another five are still hospitalised. What is a phase 1 clinical trial? That’s what this graphic aims to explain, as well as outlining the whole drug discovery process.

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The Chemistry of Cannabis & Synthetic Cannabinoids

Infographic on cannabis and synthetic cannabinoids. The main psychoactive compound in cannabis is tetrahydrocannabinol (THC), which acts on cannabinoid receptors in the brain. Synthetic cannabinoids were synthesised to investigate potential medicinal uses of cannabis and target the same receptors, but have a higher efficacy. Little is known about their effect in humans and there is a risk of a number of serious side effects. Synthetic cannabinoids can be grouped into three major groups: Classical (similar in structure to THC), aminoalkylindoles (further split into a number of subcategories) and non-classical (including cyclohexylphenols and other compounds).
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In recent years, there’s been an increase in the number of media reports on users of synthetic cannabinoids. Commonly referred to by names such as ‘Spice’ or ‘K2’, the most recent reported case involved five UK students being hospitalised after use. But what are the chemicals present in ‘spice’ and similar drugs, and what are the chemical compounds in cannabis that they aim to mimic? That’s what this graphic and post attempt to answer.

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The Chemistry of Throat Lozenges

The Chemistry of Throat Lozenges

Chemistry of Throat Lozenges
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I’ve been suffering the effects of a sore throat these past few days (the curse of the end of term cold), which inevitably got me thinking about the chemical compounds in the throat lozenges I’ve been binging on. Whilst there are a range of possible active ingredients, many throat lozenges use one (or two) of three particular compounds. This graphic takes a look at them, and how they help provide relief!

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Medicinal Chemistry - Common Components of Vaccines

A Summary of Common Vaccine Components

Medicinal Chemistry - Common Components of Vaccines Summary
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The recent measles outbreak in the US has once again provoked discussion over vaccinations, and why some parents choose not to vaccinate their children despite the benefits of doing so. Whilst not the only factor, part of the blame lies with misinformation about the chemical composition of vaccines and the effects these compounds can have. This graphic summarises some of the key components in vaccines, as well as clarifying their purpose and safety in the concentrations present.

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The Chemistry of Oral Contraceptives

The Chemistry of Oral Contraceptives

Infographic on the chemistry of oral contraceptives. Oral contraceptives contain synthetic versions of two natural hormones: estrogens and progestogens. These trick the pituitary gland into thinking a woman is already pregnant, stopping release of hormones which stimulate ovulation and preventing pregnancy. Progestogens make it difficult for sperm to reach the uterus and also make it harder for an egg to attach to the uterine lining. Progestogens can be used in combination with estrogens or on their own – which is recommended for breast-feeding women as it doesn't affect milk production. Combined pills contain an estrogen and progestogen, and are taken over a 28 day cycle.
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You may have read in the news over the past few days about the passing of Carl Djerassi, the chemist (and later, novelist) who is best known for his discovery of the first oral contraceptive. This discovery led to something of a social revolution, putting the power of contraception firmly in the hands of women, as well as changing sexual attitudes. This graphic looks at the some of the common chemicals used in oral contraceptives, and how they work.

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