Medicinal Chemistry

Six surprising side effects of medicines – in C&EN

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This month’s edition of Periodic Graphics in C&EN comes off of the back of my ending up on tetracyclines for a chest infection a month or so ago. This alerted me to their ability to make the skin of people taking them more sensitive to sunlight. It turns out that there are a number of odd and unexpected side effects of medications people take for a variety of conditions, so this graphic rounds up some of the oddest I came across. View the full graphic on the C&EN site.

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A short history of antiviral drugs – in C&EN

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COVID has generated unprecedented levels of interest in antiviral medicines, but they’re just the latest in a long line of antivirals going back almost 70 years. The latest edition of Periodic Graphics in Chemical & Engineering News looks at some of the key drugs, from the first antiviral to be approved to antivirals for HIV and Influenza, as well as briefly summarizing how some of these compounds work. View the full graphic on the C&EN site.

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A brief history of anaesthetics and how they work – in C&EN

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Surgery has become a lot more comfortable since the first demonstrations of ether anaesthesia in the 1840s. In October’s edition of Periodic Graphics in Chemical & Engineering News, we looked at the different types of anaesthesia, the compounds involved, and what we know about how they work. Click through to the C&EN site to view the full graphic.

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#ChemVsCOVID: How were the first treatments for COVID identified?

An infographic titled "Chem vs COVI timeline: 16th June 2020, RECOVERY trial shows dexamethasone as first effective COVID-19 treatment". The structure of dexamethasone is shown at the centre. The left-hand side of the graphic explains how the RECOVERY trial aimed to identify existing treatments that work against COVID-19. 12 treatments were trialled at 181 sites with over 40,000 participants. As of June 2021, 3 treatments have been shown to be effective, and 4 treatments have been shown to be ineffective. The right-hand side of the infographic explains that dexamethasone has antiinflammatory and immunosuppressant effects which may explain the positive results. It's estimated that dexamethasone has saved 22,000 lives in the UK and 1,000,000 lives worldwide. The RECOVERY trial has also shown which treatments are ineffective, including hydroxychloroquine, and set a precedent for how large-scale trials can be carried out during an emergency situation.
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On this day (16 June) a year ago, the first effective treatment for COVID-19 was announced. The corticosteroid drug dexamethasone, already used to treat several inflammatory and autoimmune conditions, was found to be effective for patients in a serious condition in hospital with COVID. This discovery was the product of the RECOVERY trial, a programme started in March 2020 to find COVID treatments.

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