Tag: cancer

World Cancer Day: How antibody–drug conjugates for cancer work

This infographic titled "Antibody-drug conjugates for cancer treatment" explains how ADCs act as "magic bullets" by combining an antibody, a linker, and a cytotoxic drug to target cancer cells. A timeline spans from Paul Ehrlich’s 1910 concept to 2025, noting that 25 ADCs are now approved globally. Diagrams illustrate ADCs binding to cancer cell antigens, entering the cell, and releasing drugs to disrupt DNA or microtubules. Future trends include bispecific ADCs and dual-drug conjugates.
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Today (4 Feb) is World Cancer Day. Analysts estimate that there will be 30.5 million new cancer cases diagnosed yearly by 2050, with a projected 18.6 million annual deaths. However, our ability to use medicines to target more effectively is improving, and antibody–drug conjugates are an increasingly effective tool in combating cancers. This graphic explains what they are, how they work, and how they might improve in the future.

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What do the IARC’s carcinogen classifications actually mean?

Infographic on the IARC carcinogen classification system. Classifications are shown along with example substances that fall within each category. Classifications range from group 1 (carcinogenic to humans) to group 4 (probably not carcinogenic).

Alcohol: Well known to be carcinogenic to humans. Despite this, a large proportion of the population drink it regularly. More surprisingly, whenever the International Agency for Research on Cancer updates its carcinogen classifications for other substances with a lower cancer risk, there’s often media fanfare. In recent years, the IARC has upgraded classifications for red meat and aspartame, leading to a spate of panicked articles. This republished and updated post takes a look at what the classification groups actually mean, and how worried we should be about a substance’s classification.

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2018 Nobel Prize Physiology-Medicine

The 2018 Nobel Prize in Physiology/Medicine: Unleashing our immune systems against cancer

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2018 Nobel Prize Physiology-Medicine
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Today saw the first of the 2018 Nobel Prizes awarded. The 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by stimulating the immune system to attack tumour cells. This graphic takes a look at the prize-winning research.

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